Objectives of Programme's Learning Outcomes

• Have acquired professional skills in relation to the objective defining the degree.
• Specialise in at least one sub-domain of chemistry.
• Learn about scientific research and the world of research.
• Help lead and complete a major development project, individually or in teams, related to chemistry.
• Mobilise, articulate and promote the knowledge and skills acquired.
• Manage research, development and innovation within chemistry and/or its applications.
• Understand unprecedented problems in chemistry.
• Communicate clearly in the scientific domain.
• Communicate, both orally and in writing, their findings, original proposals, knowledge and underlying principles, in a clear, structured and justified manner.
• Apply high quality scientific methodology.
• Demonstrate thoroughness, independence, creativity, intellectual honesty, and ethical values.

Learning Outcomes of UE

The main objective of this course is to describe the major tools used to predict the potential toxic effects of chemicals.  Consequently, at the end of this class, the students will be able to :

-  understand and describe the predictive approach based on structure-activity relationship (QSAR)

- Use the available softwares for the prediction of the metabolism and the safety of a substance from its chemical structure

- identify the most appropriate in vitro and in vivo assays for risk assessment based on the target organ

- interprete data obtained with the Ames assay

- design a study protocol for preclinical toxicology evaluation

UE Content: description and pedagogical relevance

The class will be divided in two sections:

1. in silico Models (QSAR, CADD, and expert systems)

2. in vitro et in vivo Models (mutagenicity, developmental toxicity, major target organs, and the genomics, proteomics, and metabonomics approaches applied to toxcicology)

Prior Experience

Not applicable

Type(s) and mode(s) of Q2 UE assessment

• Written examination - Face-to-face
• Production (written work, report, essay, collection, product, etc.) - To be submitted in class

Q2 UE Assessment Comments

Part I (QSAR approaches) on 10 points:
1) a series of 20 QCMS (score out of 5 points)
2) an open question (score out of 5 points)

For Part II (in vitro and in vivo tests) out of 10 points:
1) A series of 12 MCQs (6 points)
2) Exam on Practicals (4 points)

Method of calculating the overall mark for the Q2 UE assessment

The final mark of the EU out of 20 points is the sum of the marks obtained for the two AAs. In case of failure (mark < 10/20), the student will represent the two AAs

Type(s) and mode(s) of Q3 UE assessment

• Written examination - Face-to-face
• Production (written work, report, essay, collection, product, etc.) - To be submitted in class

Q3 UE Assessment Comments

same as Q2

Method of calculating the overall mark for the Q3 UE assessment

same as Q2