Objectives of Programme's Learning Outcomes

• 1. Pharmaceutical expertise: Use a foundation of concepts and knowledge in health sciences and pharmaceutical sciences.
• Understand and integrate the fundamental sciences (chemistry, physics, biology, botany) involved in the specific fields of pharmaceutical sciences
• Understand how the human body works by using knowledge of anatomy, biochemistry, physiology, immunology, microbiology and pathology under the dual approach of normal and pathological conditions in order to understand the action of medications on the body.
• Understand the basic concepts of pharmacology and pharmacokinetics
• Understand compounds for pharmaceutical application regarding their chemical structures, their structure-activity relationships, their physicochemical properties, their origins (synthetic, semi-synthetic, natural), their analytical control methods and their areas of use from a therapeutic point of view.
• 2. Scientific method: Solve pharmaceutical problems using their knowledge and critical mind.
• Understand and apply the basic principles of reasoning (obtaining data, analysis, synthesis, comparison, the rule of three, syllogism, analogy, Boolean logic, etc.)
• Use a hypothesis in inductive, deductive or abductive reasoning
• Develop a critical, practical and analytical mind
• Manage doubt and uncertainty
• Develop and rigorously manage an experimental protocol (from information gathering to the production, interpretation and presentation of results).
• 3. Communication: Communicate in an appropriate, efficient, rigorous and respectful way in a professional perspective.
• Understand the basic rules of French and of English (grammar, punctuation, connectors, etc.).
• Use a rich vocabulary linking concepts and words accurately
• Adapt lexical and syntactic choices in communication register (everyday language, medical language or scientific terminology)
• Summarise, explain, and argue
• Share knowledge and information
• 4. Sense of responsibility: Act ethically and professionally.
• Understand a global approach to health incorporating prevention and screening
• Identify community health problems in the various teachings
• Be aware of the concept of "pharmaceutical care"
• Base their reasoning on the data from the scientific literature
• Show loyalty and scientific honesty (in teamwork and in respecting the results and the work of others)
• 5. Quality: Assess themself, expand their knowledge and adapt their attitude.
• Manage time
• Prioritise
• Understand the organisation of the health system and its social dimension
• Be aware of the concepts of good business practices and quality management.
• Have developed an interest in the medical-pharmaceutical field
• Locate scientific information efficiently
• Research, read, interpret, and critique a scientific paper with sufficient knowledge of scientific English
• Compare different sources of information

Learning Outcomes of UE

At the end of this course, the students will be able to :

- describe the different phases of the biotransformation of toxicants
- explain the bioactivation process and its role in toxicology
- define and explain the major toxicological concepts (target organ, dose, mode of action, ...)
- describe the conventional procedures of risk assessment
- describe the main mechanisms of toxicity of chemicals ( for example oxuidative stress, disruption of calcium homeostasis, alteration in cell proliferation during tissue repair)
- differenciate and explain the mechanisms of necrosis and apoptosis
- explain the importance of covalent binding of chemicals to macromolecules
- describe the mechanisms of immunotoxicity and enzymes inactivation
- Understand the role of nuclear receptors and signalling pathways in toxic mechanisms

UE Content: description and pedagogical relevance

1. Concepts in ADME (Administration, Distribution, Metabolism, Elimination)

2. Biotransformation and bioactivation of chemicals

3. Modulators of toxic effetcs

4. Conventional procedures of risk assessment

5. Major toxic mechanisms (oxidative stress, disruption of calcium homeostasis, necrosis and apoptosis, cell proliferaiton, covanlent binding to macromolecules, immunotoxicity, enzymes inactivation, interaction with ionic transporters)

Prior Experience

Fundamentals in biology and chemistry