Content of Learning Activity

I.Introduction   I.1.  Terminology   a.  Controlled release   b.  Prolonged-Sustained release   c.  Drug targeting   I.2.  Objectives of controlled release drugs II.Factors Influencing the Design and Operation of Controlled / Extended-Release Drugs III. Physicochemical properties of the drug substances influencing the design and the efficacy of the dosage form       a. Partition Coefficient       b. Degree of ionization       c. Molar mass and molecular volume       d. Solubility        e. Stability        f. Protein binding IV.Biological properties of the drug substance influencing the design and efficacy of a controlled / prolonged release drug   IV.1.  Absorption   IV.2.  Distribution   IV.3.  Metabolisation   IV.4.  Elimination V.Controlled release forms   a.  Twox classes   b.  Polymers employed   b.1.  Glossary of polymer used   b.1.1.  Natural polymers   b.1.2.  Synthetic polymers               A.  Carbonated polymers               B.  Polymers with heteroatoms   c.  Microencapsulation   c.1.  Application of micro/nanoencapsulation   c.2.  Incorporation of drugs   -  Chemical conjugation (prodrug)   -  Physical entrapment   -  Polyionic complexation   d.  Nanovectorisation of drugs and tumor targeting   d.1.  Definition and illustrations   d.2.  First generation vectors   d.3.  Second generation vectors   d.4.  Third generation vectors   d.5.  Tumor targeting  

Required Learning Resources/Tools

"Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists" Eds. Hillery, Lloyd and Swarbrick, 2001 Taylor & Francis

Recommended Learning Resources/Tools

Not applicable

Other Recommended Reading

Not applicable

Mode of delivery

• Remote

Type of Teaching Activity/Activities

• Cours magistraux

Evaluations

The assessment methods of the Learning Activity (AA) are specified in the course description of the corresponding Educational Component (UE)