Content of Learning Activity

- Pharmacokinetics: the fate of a drug after administration to a patient in four main steps: Absorption, Distribution, Metabolism, and Elimination (in practical sessions, main pharmacokinetic parameters will be explored in exercises (using MS Excel), and metabolism phases will be exemplified in a specific predictive software using formula of common drugs).
- Pharmacodynamics: pharmacological (therapeutic) effect of a drug on a cell in a tissue, organ, subsequently to interaction with its main target molecule (several types of receptor (Gprotein-coupled, protein kinase-coupled, guanilyl-cyclase-coupled...), ion channels and pumps, enzymes...)
- Toxicology: mechanisms of toxicity induced by xenobiotics (drugs, toxins, synthetic chemicals, pesticids...): bioactivation of a xenobiotic in a toxic metabolite, organ sensitivity, prooxidant action, carcinogenicity, endocrine disruption..., In practical sessions; software for prediction of drug/xenobiotic/metabolite toxicity (based of structure-activity relationship) will be handled (chemical groups inducing cell stress (oxidative), genotoxicity...)

Required Learning Resources/Tools

Powerpoint slides as pdf file

Recommended Learning Resources/Tools

Not applicable

Other Recommended Reading

As suggestion (not mandatory):
B. Katzung; Basic & Clinical Pharmacology
U. Boelsterli; Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition
Landry & Gies; Pharmacologie: Des cibles vers l'indication thérapeutique

Mode of delivery

• Face-to-face

Type of Teaching Activity/Activities

• Cours magistraux
• Travaux pratiques

Evaluations

The assessment methods of the Learning Activity (AA) are specified in the course description of the corresponding Educational Component (UE)