Content of Learning Activity

Reminder in Neurophysiology/Neuropharmacology: Structures, Functions of Nervous System (NS), neurotransmitters, barriers, metabolism, development. Pharmacology, Safety pharmacology, Toxicology notions: class effects, on-target & off target effects, dose, concentration, brain penetration, routes of administration...
Safety Pharmacology: Regulatory requirement for Nervous System, Acute & functional effects, Neurobehavioural assessment, Seizure liability, Drug abuse potential, Testing
Neurotoxicology (mature organisms): Regulatory requirement (drug, chemicals), Toxic Syndromes, Heavy metals, Gaz, Chemical compounds, Pesticids, Alcohol, Neurotoxins: animal, plants, mushrooms, bacteria.. Testing
Developmental Neurotoxicology: NS Development, critical periods, Regulatory requirement, Heavy metals, chemical compounds, pesticids, alcohol, tobacco, Testing
Endocrine disruptors: effects during NS development, effects on sex specific brain regions
Risk assessment: Hazard identification, on/off target effect, intrinsic toxicity, DMPK, exposure, risk evaluation and mitigation, population, acute and long-term effects

Required Learning Resources/Tools

Not applicable

Recommended Learning Resources/Tools

Not applicable

Other Recommended Reading

Toxicologie clinique, de Baud & Garnier (2017) Lavoisier Médecine Ed.
Handbook of developmental Neurotoxicology, Slikker et al. (2018) Academic Press Ed.

Mode of delivery

• Mixed

Type of Teaching Activity/Activities

• Cours magistraux

Evaluations

The assessment methods of the Learning Activity (AA) are specified in the course description of the corresponding Educational Component (UE)