Content of Learning Activity

The course will be scheduled according to the following major plan:
- definition of biomarkers and presentation of the identification methodology;
- definition of the targeted molecular ligand;
- presentation of the high throughput screening methodology used in the discovery of the active pharmaceutical compounds;
- presentation of the methodology used to validate the active pharmaceutical compounds.
- the exigencies and advantages of the in vivo molecular imaging;
- molecular imaging of the cardiovascular system;
- molecular imaging of the nervous system;
- imaging of the liver function;
- molecular imaging of the renal function;
- cancer imaging
 

Required Learning Resources/Tools

Copies of the PowerPoint presentations are available on the Moodle platform.

Recommended Learning Resources/Tools

Sans objet

Other Recommended Reading

- High throughput screening: the discovery of bioactive substances, Devlin JP, Ed, CRC Press, 1997.
- High-Throughput Screening in Drug Discovery, Jörg Hüser J, Mannhold R, Kubinyi H, Folkers G (editors), Wiley-VCH, 2006.
- High Throughput Screening: Methods and Protocols, Janzen WP, Humana Press Inc., U.S., 2002
- Phage display: A practical approach, Clackson T, Lowman HB, Eds, Oxford University Press Inc, New York, 2004
- Phage display in biotechnology and drug discovery, Sidhu SS, Ed, CRC Press, Taylor & Francis Group, USA, 2005.

Mode of delivery

• Mixed

Type of Teaching Activity/Activities

• Cours magistraux
• Conférences

Evaluations

The assessment methods of the Learning Activity (AA) are specified in the course description of the corresponding Educational Component (UE)