Objectives of Programme's Learning Outcomes

• Understand, describe, analyse and prioritise biological phenomena
• Understand basic scientific knowledge and be able to use it
• Problem-solve
• Understand the expression of biological realities in absolute or relative terms, the orders of magnitude, proportions and probability
• Abstract, understand and apply mathematical translations of the main laws and biological phenomena
• Understand and use different graphical representations of numerical values and their relationships
• Perceive spatial distribution, and understand two- and three-dimensional representations and interconvert them
• Understand the chronology of a phenomenon and master the time scales and their representations
• Manipulate concepts of concentration and prepare solutions
• Control the molecular, morphological and functional approaches of normal and pathological conditions
• Understand the learning of physiological and pharmacological reasoning
• Understand experimental protocols in the biomedical domain
• Integrate concepts from different approaches/disciplines in a complex biomedical problem
• Explain how molecular, morphological and functional modifications constitute pathological states and vice versa
• Develop reasoning skills
• Understand and apply the basic principles of reasoning (obtaining data, analysis, synthesis, comparison, the rule of three, syllogism, analogy, Boolean logic, etc.)
• Work with efficiency / accuracy / precision
• Develop critical thinking, test and monitor conclusions understanding the domain of validity, and explore alternative hypotheses
• Demonstrate developed interpersonal skills
• Use a rich vocabulary linking concepts and words accurately
• Adapt lexical and syntactic choices in communication register (everyday language, medical language or scientific terminology)
• Summarise, explain, and argue
• Work in a team
• Share knowledge and information
• Submit reviews, reports and give oral presentations
• Manage resources
• Manage time
• Use basic IT and bibliographic resources.
• Manage their studies
• Locate scientific information efficiently
• Compare different sources of information
• Read, interpret, and critique a scientific article
• Be open to research and demonstrate scientific curiosity
• Show a good knowledge of scientific English
• Understand and summarise a scientific article in English

Learning Outcomes of UE

Students will complete their knowledge on the gene expression as well as on protein functions. Therefore, at the end of the lecture, the basic principles associated with the genetic material will be acquired. The lecture will discuss new concepts and advanced methodologies in the area of molecular biology, including the new generation sequencing. Theoretical concepts will help the students to extract information from public databases (internet) and understand published scientific results. During practical work in laboratory, they will perform several techniques such as cloning and manipulation of recombinant DNA (PCR, cloning, determination and computer analysis of sequences).

Content of UE

After a review of the structure of DNA, its modifications and gene expression ( replication , transcription, translation and compensation ), the course will cover the main techniques related to molecular biology , the genetic engineering ( electrophoresis of DNA , DNA cloning , restriction enzyme , ...) to transgenesis ; but also more modern techniques derived from the discovery of the human genome as microarray DNA , or pharmacogenomics techniques that lead us towards personalized medicine . The exercises and practical work will illustrate the theoretical lecture.   The student will learn (1) how to understand and perform an experimental protocol, (2) how to analyse data and look for information on internet, (3) how to set up the best strategy to answer a scientific question. Moreover, during a team work "Du gène à la physiopathologie: une approche intégrée ", the students will have reminders of the specific biochemistry notions to realize the work. Demonstration of the use of different databases requisite to realize the work. Group exercise on a specific case from a gene acronym and a pathology.

Prior Experience

General Biochemistry II

Type of Assessment for UE in Q2

• Presentation and/or works
• Written examination
• Practical test
• Graded tests

Q2 UE Assessment Comments

Lecture = open-ended questions and/or MCQ and/or right or false
Practical work = evaluated report, scored exercises + final test
Weighting = 10 % of total score
Section « Du gène à la physiopathologie : une approche intégrée » = presentation of a work (article) Weighting = 10 % of total score

Type of Assessment for UE in Q3

• Written examination

Q3 UE Assessment Comments

  The Q3 evaluation will be based on the lecture = MCQ and/or open-ended questions and/or right or false. The score reached in Q2 regarding practical work and presentation of an article will be added in Q3 fo a weighting of 20%.