Nanotechnology - Controlled Release Systems

		Study programme 2018-2019	Français
		Nanotechnology - Controlled Release Systems
		Activité d'apprentissage à la Faculty of Science

Code	Lecturer(s)	Associate Lecturer(s)	Subsitute Lecturer(s) et other(s)
S-CHIM-077	COULEMBIER Olivier

Language of instruction	Language of assessment	HT(*)	HTPE(*)	HTPS(*)	HR(*)	HD(*)	Term
Français	Français	15	0	0	0	0	Q2

Content of Learning Activity

I.Introduction I.1. Terminology a. Controlled release b. Prolonged-Sustained release c. Drug targeting I.2. Objectives of controlled release drugs II.Factors Influencing the Design and Operation of Controlled / Extended-Release Drugs III. Physicochemical properties of the drug substances influencing the design and the efficacy of the dosage form a. Partition Coefficient b. Degree of ionization c. Molar mass and molecular volume d. Solubility e. Stability f. Protein binding IV.Biological properties of the drug substance influencing the design and efficacy of a controlled / prolonged release drug IV.1. Absorption IV.2. Distribution IV.3. Metabolisation IV.4. Elimination V.Controlled release forms a. Twox classes b. Polymers employed b.1. Glossary of polymer used b.1.1. Natural polymers b.1.2. Synthetic polymers A. Carbonated polymers B. Polymers with heteroatoms c. Microencapsulation c.1. Application of micro/nanoencapsulation c.2. Incorporation of drugs - Chemical conjugation (prodrug) - Physical entrapment - Polyionic complexation d. Nanovectorisation of drugs and tumor targeting d.1. Definition and illustrations d.2. First generation vectors d.3. Second generation vectors d.4. Third generation vectors d.5. Tumor targeting

Required Learning Resources/Tools

"Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists" Eds. Hillery, Lloyd and Swarbrick, 2001 Taylor & Francis

Recommended Learning Resources/Tools

Not applicable