Objectives of general skills

• Imagine, design, implement and operate compounds, products and materials to specific properties and physical, chemical and biochemical solutions/processes leading to obtaining these materials by integrating needs, contexts and issues (technical, economic, societal, ethical, safety and environmental).
• Identify complex problems to be solved and formulate the specifications by integrating client needs, contexts and issues (technical, economic, societal, ethical and environmental).
• Based on modelling, design one or more products/processes/solutions addressing the problem raised; evaluate them in light of various parameters of the specifications.
• Evaluate the approach and results for their adaptation (optimisation, quality, environment, safety/security).
• Mobilise a structured set of scientific knowledge and skills and specialised techniques in order to carry out missions of chemical engineering and materials science, using their expertise and adaptability.
• Master and appropriately apply knowledge, models, methods and techniques specific to the field of chemistry and materials science.
• Analyse and model a problem/process/producing pathway by critically selecting theories and methodological approaches (modelling, calculations), and taking into account multidisciplinary aspects.
• Assess the validity of models and results in view of the state of science and characteristics of the problem.
• Communicate and exchange information in a structured way - orally, graphically and in writing, in French and in one or more other languages - scientifically, culturally, technically and interpersonally, by adapting to the intended purpose and the relevant public.
• Argue to and persuade customers, teachers and a board, both orally and in writing
• Select and use the written and oral communication methods and materials adapted to the intended purpose and the relevant public.
• Use and produce scientific and technical documents (reports, plans, specifications, etc.) adapted to the intended purpose and the relevant public.
• Adopt a professional and responsible approach, showing an open and critical mind in an independent professional development process.
• Show an open and critical mind by bringing to light technical and non-technical issues of analysed problems and proposed solutions.
• Exploit the different means available in order to inform and train independently.

UE's Learning outcomes

The course on industrial biotechnology introduction enables students to acquire the following knowledge: - know the main components of a cell and their functions; - understand cellular function (metabolism, replication, enzymology); - Represent enzymatic and microbial reactions through appropriate kinetic laws; - Understand and use the basics of engineering biological processes ; - Understand the complexity of extrapolating a process from a laboratory to a driver and then to an industry; - Understand online monitoring and regulation problems - Choose a method of separation / purification based on the constraints

UE Content

This course is divided into parts. The first part is dedicated to the fundamentals of biochemistry, microbiology, metabolism and enzymology. Some legal and normative concepts are taught (contained use, security level laboratories). The biocatalysis and bioreactor aspects are then discussed by the characterisation of the mechanisms (enzymatic and microbial biocatalysis), and engineering microbial bioreactors (flows, continuous reactors, batch, fed-batch, airlift, the balance sheets of materials, heat exchanges). Associated with these descriptions, scale up problems and monitoring of processes are presented. Some examples of models such as metabolic fluxes, structured models, macroscopic models are detailed. The purification aspects (membranes, chromatography, precipitation, etc.) are then discussed in the light of the final use of bioproduct. Some examples of major industrial bioprocesses are described (antibodies, vaccines, bioethanol, biogas, treatment of urban waters).

Prior experience

Organic chemistry basic concepts (structure, function, spatial representations) and basic laboratory techniques (analytical and organic chemistry) are required to follow this course unit.